• Till date several predictive models have been

  2020-07-13

  

  Till date, several predictive models have been developed by different research groups to speed up the process of library selection and drug optimization (Walters et al., 1999, Caldwell, 2000, Plewczynski et al., 2006, Wang and Ramnarayan, 1999, Pogorelcnik et al., 2015, Greenbaum et al., 2002, Sadow

• The annotation is arguably the

  2020-07-13

  

  The annotation is arguably the most important part of analysis, as it enables one to evaluate and interpret the content of the transcriptome assembly. In this context, the non-redundant contigs were initially run in BLAST against the Nr database showing that 55% of them displayed high similarity to

• br Introduction The dopaminergic system and its projections

  2020-07-13

  

  Introduction The dopaminergic system and its projections including both the prefrontal SB-222200 (PFC) and striatum are known as being crucial to synaptic plasticity, skill acquisition and higher order functions (e.g., working memory and cognitive control; Matsumoto et al., 2003). Variations in d

• Cytidine 5-triphosphate The present study has shown

  2020-07-13

  

  The present study has shown that additional protein stability can be achieved (Fig. 6). The 0.6 to 1.0 °C increases that were observed were not large compared, for example, to the ∼5 °C increase that has been reported using sequence modifications [22]. This may reflect that the Hyp enters both the X

• br Objectives br Study design Thirty KTx http www

  2020-07-13

  

  Objectives Study design Thirty KTx recipients were enrolled in this pilot study from December 2015 to May 2016. Patient demographics are presented in Table 1. The inclusion criteria were: age ≥ 18 years and CMV-IgG serostatus (D+/R−, D+/R+, D−/R+) pre-Tx. All patients were enrolled during the

• br Ubiquitin Capture by the Mobile APC

  2020-07-11

  

  Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the NSC59984 correlates with processivity of

• The all NTP pyrophosphatase and NUDIX families maintain the

  2020-07-11

  

  The all-α NTP pyrophosphatase and NUDIX families maintain the deoxynucleotide triphosphate (dNTP) pool balance, limit the incorporation of harmful nucleotides, and represent a promising therapeutic approach to develop anticancer and immunosuppressive agents., , , , Among these housekeeping enzymes

• It has been reported that

  2020-07-11

  

  It has been reported that PGE2 increases expression of the survivin mRNA (Baratelli et al. 2005) and promotes the stabilization of the survivin protein in some tumor SB-715992 sale (Krysan et al. 2003). However, it is unclear whether PGE2 affects the expression of survivin mRNA or promotes the stabi

• br Introduction Our understanding of how ligands interact wi

  2020-07-11

  

  Introduction Our understanding of how ligands interact with G protein coupled receptors is evolving, particularly the recognition that some have the ability to preferentially activate a subset of intracellular signalling cascades – so called pathway biased ligands [1]. Additionally, it is now acc

• br Materials and methods br Results br Discussion Plant

  2020-07-11

  

  Materials and methods Results Discussion Plant U-box E3 Ub ligases regulate diverse plant-specific cellular processes [1], [2], [3], [4]. However, structural and functional relationships between U-box E3s and their E2 partners are largely unknown in higher plants [24], [25]. In this study,

• Introduction Trichloroacetic acid TCA might enhance the acti

  2020-07-11

  

  Introduction Trichloroacetic Dioscin (TCA) might enhance the activation of T cells and disrupt various activities of peripheral T cells [1], which is related to human immune function and reduces human immunity. Trichloroethylene (TCE) has been widely used in many manufacturing industries [2], and

• Tosedostat A cocktail approach can detect the activities of

  2020-07-10

  

  A cocktail approach can detect the activities of multiple CYP 450 isoforms following administration of multiple CYP-specific substrates in a single experiment. Caffeine, losartan, omeprazole, dextromethorphan and midazolam are often used as substrates in “cocktail probes” of human cytochrome CYP1A2,

• The mechanism by which these HIV PIs impair skeletal muscle

  2020-07-10

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty bapta am translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular membranes. It

• br Acknowledgements br A subgroup of pediatric solid neoplas

  2020-07-10

  

  Acknowledgements A subgroup of pediatric solid neoplasms, collectively referred to as small round cell tumors (SRCTs) of childhood, demonstrates undifferentiated small round cell morphological characteristics. The SRCTs include neuroblastomas, lymphomas, and several bone and soft tissue sarcoma

• Protein kinase casein kinase CK comprises a family

  2020-07-09

  

  Protein kinase casein kinase 1 (CK1) comprises a family of highly related, constitutively active serine/threonine protein kinases (reviewed by [15]). CK1 is involved in controlling a wide variety of different cellular events including protein turnover [16], [17], nuclear import [18] and the cellular

14742 records 786/983 page Previous Next First page 上5页 786787788789790 下5页 Last page