• The corticotropin releasing factor CRF also

  2020-08-05

  

  The corticotropin-releasing factor (CRF) also referred to as corticotropin-releasing hormone, is a key mediator of mammalian endocrine, behavioral, autonomic, and immune responses to stress (Vale et al., 1981, Owens and Nemeroff, 1991, Bale and Vale, 2004). Within the hypothalamic–pituitary–adrenal

• The results of our study demonstrated that HSL activation

  2020-08-05

  

  The results of our study demonstrated that HSL activation by kinsenoside-mediated PKA activation was coordinated with perilipin phosphorylation and facilitated efficient lipolysis, resulting in increased glycerol release and decreased lipid accumulation. The localization and interplay of perilipin a

• Kaempferol sale Impulsive burying and freezing behaviors in

  2020-08-05

  

  Impulsive burying and freezing behaviors in response to aversive stimuli may represent attempts to avoid novel and/or aversive stimuli. These behaviors can be assessed utilizing the marble burying and conditioned fear tasks, respectively. For example, Wistar rats in proestrus and ovariectomized rats

• lfm We also used an affinity purification approach

  2020-08-05

  

  We also used an affinity purification approach and subsequent mass spectrometry analysis to explore the interacting proteins with METTL8, and found a number of RNA binding proteins in the candidates list (Table S3). This result suggests that the binding between METTL8 and Mapkbp1 mRNA may be not dir

• br The effect of EWS FLI expression in tumor

  2020-08-05

  

  The effect of EWS-FLI-1 expression in tumor development A major impediment toward understanding sarcoma biology in general and in ESFT biology in particular, is the lack of adequate transgenic animal models. Thus far, development of a transgenic Ewing’s sarcoma model in mice has failed, probably

• The termini of the substrate recognition and catalytic

  2020-08-04

  

  The termini of the substrate recognition and catalytic modules are anchored to opposite sides of the scaffold so that they face each other. Within the substrate recognition module, the coactivators CDC20 and CDH1 have three domains: intrinsically disordered N- and C-terminal regions containing so-ca

• Of the acidic hydroxyazoles involved

  2020-08-04

  

  Of the acidic hydroxyazoles involved, hydroxypyrazole had the weakest acidic profile (pKa in the range of 6–7), although highly deprotonated at physiological pH. During hit optimization, the two pyrazole ring positions available for substitution provide an opportunity for a better exploration of the

• Both the p Leu Pro and the p

  2020-08-04

  

  Both the p.Leu610Pro and the p.Tyr740Cys substitutions are located in the kinase domain of the DDR2 receptor. To study the consequences of these substitutions, we first examined DDR2 autophosphorylation. All results were reproduced in at least two independent experiments. Control fibroblasts and fib

• br Acknowledgments This work was supported

  2020-08-04

  

  Acknowledgments This work was supported in part by Grants-in-Aid for Scientific Research (KAKENHI), a Research Fellowship for Young Scientists (Y.O.), a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) and the Program for Advancing Strategic Internati

• Carmofur receptor Another interesting study was that by Koty

  2020-08-04

  

  Another interesting study was that by Kotyuk et al. (2015), who investigated the association between COMT rs4680 and personality in elderly people. The authors analysed the association between COMT rs4680 and NEO-FFI. The GG Carmofur receptor correlated with lower mean Neuroticism score and higher A

• br Conflicts of interest br Acknowledgments This study

  2020-08-04

  

  Conflicts of interest Acknowledgments This study was supported by the Beijing Natural Science Foundation (No.7192015), the Great Wall scholars program of Beijing Municipal Education Commission (No.CIT&TCD20180308) and Beijing Municipal Commission of Education Research Projects (Grant No. KM201

• Previous studies have induced EphB

  2020-08-04

  

  Previous studies have induced EphB4 signaling by artificially preclustering ephrin-B2 in solution to generate multimeric receptor-ligand complexes (22, 23). However, these methods do not recapitulate the physical interactions between membrane-bound receptors and ligands. We therefore turned to suppo

• TREM is found in various tissue macrophages including

  2020-08-04

  

  TREM2 is found in various tissue macrophages, including CNS microglia and monocyte derived dendritic NAD/NADH Quantitation Colorimetric Kit (Paloneva et al., 2002, Colonna and Wang, 2016). We found that both TREM2 and its adaptor protein DAP12 (Peng et al., 2010) are reduced after DDR1 and DDR2 knoc

• In the present study BACH downregulation did not correlate

  2020-08-04

  

  In the present study, BACH1 downregulation did not correlate with nuclear accumulation of NRF2, suggesting that these changes were triggered via an independent mechanism. BACH1 is a transcriptional repressor that is regulated by heme. Heme binding to the BACH1 C-terminal domain inhibits BACH1 DNA bi

• Wilkinson et al demonstrated that a non

  2020-08-04

  

  Wilkinson et al. (1990) demonstrated that a non-hydrolyzable analog of the ubiquitin adenylate could potently inhibit the ubi-quitin-activating enzyme. Later, Ub-AMSN and SUMO-AMSN probes, which mimic the ubiquitin and SUMO adenylates, respectively, were shown to selectively inhibit Uba1 and the SUM

14742 records 774/983 page Previous Next First page 上5页 771772773774775 下5页 Last page