• Four m thick sections of formalin

  2020-07-02

  

  Four-μm thick sections of formalin-fixed paraffin-embedded tissue samples from uterine cervical cancers were cut with a microtome and dried overnight at 37 °C on a silanized-slide (Dako, Carpentaria, CA, USA). The protocol of the universal Dako Labeled Streptavidin–Biotin kit (Dako) was followed for

• Another interesting finding regarding substrate selectivity

  2020-07-02

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty ITSA1 at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute a maj

• br Materials and methods br Results br Discussion

  2020-07-02

  

  Materials and methods Results Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive. In this study, we present evidence sh

• PJ 34 Our data show a site specific interaction of

  2020-07-02

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• Furosemide In conclusion we demonstrated phenoconversion

  2020-07-02

  

  In conclusion, we demonstrated phenoconversion of CYP3A in stable kidney transplant recipients, and that higher plasma indoxyl sulfate concentrations in these subjects may be involved in the phenomenon. The present findings suggest that dose adjustment of drugs metabolized by CYP3A may be needed in

• Cyclic di-GMP Mitophagy is a selective autophagic process wh

  2020-07-02

  

  Mitophagy is a selective autophagic process which leads to the degradation of damaged mitochondria in response to metabolic or environmental stress conditions. In this study, we found that LFS-01 treatment significantly enhances p62 in a time-dependent manner. We found that the upregulation of p62 i

• In this study we characterized the

  2020-07-02

  

  In this study, we characterized the metabolic function of tra2 in the Drosophila fat body. Similar to the 9G8 phenotype, decreasing tra2 levels in the Drosophila fat body using RNAi resulted in increased starvation resistance and a large increase in triglycerides. This increased storage of triglycer

• ARA metabolites which are produced through cytochrome

  2020-07-01

  

  ARA metabolites, which are produced through cytochrome P450 (CYP450) enzymes influence cardiovascular homeostasis. Human CYP4A11 and CYP1A2 metabolize ARA to 20-hydroxyecostearonic 4-DAMP (20-HETE) [11], which is a vasoconstrictor [12], platelet activator [13] and naturetic in the kidney [14]. On th

• Apart from its high affinity

  2020-07-01

  

  Apart from its high affinity, the selection of GW2580 as monoamine oxidase inhibitors lead in our radiotracer development program was motivated by its exceptional selectivity. The observed profound impact of small structural modifications on the selected panel of four kinases tested prompted us to c

• Materials and methods br Results br Discussion Hydroxylation

  2020-07-01

  

  Materials and methods Results Discussion Hydroxylation of proline in bacterial AACOCF3 is one of the oxygen-requiring metabolic reactions, which needs efficient oxygen. Oxygen supply is always a rate-limiting step for tyrosinase production even though pure oxygen is purged in a bioreactor (3

• Another significant finding in our study was the demonstrati

  2020-07-01

  

  Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in CL 316243 disodium salt sale (Fig. 11). Because of the consistent protection conferred by CK2 inhibiti

• The T cell receptor TCR pathway is associated with

  2020-07-01

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• Phenolic compounds generated during biomass pretreatment inh

  2020-07-01

  

  Phenolic compounds generated during ion channels pretreatment inhibit and/or deactivate cellulolytic/hemicellulolytic enzymes as well as the viability and fermentative capacity of yeast and bacteria [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]. Phenolic compounds cause changes in protein co

• The discovery of proteases that are active in organic

  2020-07-01

  

  The discovery of proteases that are active in organic solvent media has greatly extended their ability in the synthesis of useful products. Microbial proteases which are able be catalyse in non-aqueous solvents present new expectation in enzyme applications. This kind of enzymes gives a major contri

• The AURA trial was a phase I II study evaluating

  2020-07-01

  

  The AURA trial was a phase I/II study evaluating the safety, tolerability and activity of Osimertinib in patients with EGFR-mutated NSCLC progressing after a previous EGFR TKI. The phase I component of the study included a dose escalation part (Osimertinib 20mg to 240mg), using a rolling six design,

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