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Flexible alignment of isopropylphenylaminobenzimidazole with
2020-11-17
Flexible alignment of 7-isopropylphenylaminobenzimidazole 16 with the lead 3X FLAG tag Peptide receptor 1 was performed using MOE. It was found that the aryl group of compound 16, exemplified as a yellow circle in Figure 2, overlapped well with the corresponding alkyl chain of compound 1 as well as
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The regression also revealed a significant
2020-11-17
The regression also revealed a significant association between admission selectivity (SELECT) and exam pass rate (PASS%) (p Bestatin hydrochloride serve as an indicator of a student’s ability to learn and their aptitude for academic success. These same qualities likely enable more selective schools
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br Methodology The following subsections describe
2020-11-17
Methodology The following subsections describe the steps of the Systematic Literature Review (SLR) process we followed [9]. Results In our review of the literature, we used the definitions provided by the IEEE Standard Computer Dictionary [15] to categorize the claims about the effectiveness
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As the COMT enzyme is primarily
2020-11-17
As the COMT enzyme is primarily related to prefrontal dopamine degradation (e.g., Yavich et al., 2007), the present study supports the notion that prefrontal dopamine modulates retention of fear extinction rather than within-session extinction (Abraham et al., 2014). Consistent with other studies we
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It should be noted that not only glyphosate but
2020-11-17
It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the 1,4-DPCA regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2 on other te
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br Results and discussion Analysis of experimental
2020-11-17
Results and discussion Analysis of experimental data indicates that the radon ML-265 coefficient in OPC blended with RHA varies from 0.15 × 10−6 m2 s−1 for pure cement to 0.26 × 10−6 m2 s−1 for cement mixed with 50% RHA by weight. The value of diffusion coefficient first decreases in cement with
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Building s constructional elements should be able to
2020-11-17
Building's constructional elements should be able to protect residents from the negative effect of noise caused by surroundings [19]. The World Health Organization estimates that each year more than one million Healthy Life Years are lost in the European Union member states and other Western Europea
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Given that dimethylamine substitution was
2020-11-17
Given that dimethylamine substitution was tolerated as in SR106447 (), we investigated perhexiline amine substitutions as replacements for the -butyl group (). Cyclic amines (SR19880, 19882) or simple mono-substituted anilines (SR20037) were not active, nor was an acetylated version (SR20039). The s
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PGE exerts its functions by binding to different
2020-11-17
PGE2 exerts its functions by binding to different receptors. Four different subtypes of PGE2 receptors are found in mammals and are designated as EP1-4. These are G-protein coupled receptors that belong to a family of seven rhodopsin-like transmembrane spanning receptors. They are structurally diffe
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Only a few studies have examined the effect
2020-11-17
Only a few studies have examined the effect of prostanoids on cardiac fibroblasts. Therefore, this study examines the effect of PGE2 on cardiac fibroblast proliferation and tests the hypothesis that PGE2 causes cardiac fibroblast proliferation via alterations of ptc chemical regulatory molecules and
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Neonatal hydronephrosis induced by TCDD exposure
2020-11-17
Neonatal hydronephrosis induced by TCDD exposure via lactation has a critical window for onset: the incidence of this disease peaks around PNDs 1–4, followed by a rapid decrease to a substantially null level in adulthood (Couture-Haws et al., 1991; Yoshioka et al., 2016). The EP1 protein was localiz
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A previous pharmacokinetic study of curcumin in mice demonst
2020-11-16
A previous pharmacokinetic study of curcumin in mice demonstrated that curcumin could not be detected in plasma after a single oral dose of 75 mg/kg of curcumin. After 4-months administration of 75 and 300 mg/kg of curcumin, plasma levels of curcumin and THC were 0.095 and 0.465 μM and 0.025 and 0.1
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The ubiquitin like modifier NEDD
2020-11-16
The ubiquitin-like modifier NEDD8 (NEURAL PRECURSOR CELL EXPRESSED, DEVELOPMENTALLY DOWN-REGULATED 8) uses similar enzymatic machineries for NEDD8 conjugation as ubiquitin (Figure 1) [11, 12, 13, 14]. In plants as well as in other eukaryotes, the number of E3 ligases for NEDD8 and the number of know
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Previous studies have indicated that hSSB
2020-11-16
Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho
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L-Glutamine australia br Introduction In mammals there are t
2020-11-16
Introduction In mammals there are ten known isoforms of the enzyme diacylglycerol kinase (DGK), as well as gene splice variants. Enzymes of this family all have a homologous active site but differ widely in their molecular mass, mechanisms of activation and biological function (Shulga et al., 201
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