• It has previously been shown that human melanocytes are

  2021-02-02

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Sotalol on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that the res

• Fujimoto et al pointed out that RPN

  2021-02-02

  

  Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC Adenine mg (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irinotecan, docetaxel, doxorubicin, oxal

• Inflammatory action of certain cytokines can influence cell

  2021-02-02

  

  Inflammatory action of certain cytokines can influence cell proliferative routes (Deshmane et al., 2009). When mTOR is inhibited, for instance by the action of Rapa, TGF-β1, which has an anti-inflammatory action, is increased. The relationship between high levels of TGF-β1 and FIPI arrest has been

• Characterization factor is another variable

  2021-02-01

  

  Characterization factor is another variable suggested in the presented correlation. Specific gravity (SG) and normal boiling point of hydrocarbons are needed to calculate Watson characterization factor [61], [62]: The boiling point of bitumen cannot be precisely measured, because bitumens contain e

• br Methods br Results br

  2021-02-01

  

  Methods Results Discussion Literature showed SN was well studied for its antigastric ulcer, antiinflammatory, antihyperglycemic, and antihyperlipidemic properties. Although a recent publication reported that SN was found to exert its regulatory effect in animal cholesterol levels, the exact

• Endothelial dysfunction has been associated with

  2021-02-01

  

  Endothelial dysfunction has been associated with most of the established cardiovascular risk factors, such as hypercholesterolemia, hypertension, smoking, diabetes mellitus, a positive history of premature CAD and elevated tetrandrine homocysteine 4, 26, 27. Endothelial dysfunction is present in th

• Angiotensin 1/2 (1-7) amide Our previous high throughput scr

  2021-02-01

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based Angiotensin 1/2 (1-7) amide assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20

• Compound was prepared from chloroindole by

  2021-02-01

  

  Compound was prepared from 6-chloroindole () () by acylation, to give , and subsequent reduction to give . The thiazole was then installed using conditions developed by Buchwald and co-workers to give . Hydrolysis of the ester yielded the thiazole nampt inhibitor derivative (). Derivatives and were

• In vasculature NADPH oxidases NOXs are the

  2021-02-01

  

  In vasculature, NADPH oxidases (NOXs) are the main sources of O2− generation that involve in the transfer of electrons to molecular oxygen. Endothelin-1 [25] and thromboxane A2 [26] were reported to induce eNOS uncoupling via upregulation of NOXs. Additionally, inhibition of p47 phox, a subunit of N

• br Experimental Procedures br Author Contributions br

  2021-02-01

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In addition to the HLA region numerous other loci have shown association with type 1 diabetes risk [1], and susceptibility trpv1 antagonist have been identified in many of these regions [2]. How these genes exert

• The importance of EBI for

  2021-02-01

  

  The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed Camptothecin synthesis and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involv

• br Materials and methods br Results br Discussion

  2021-02-01

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important rilpivirine of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation sys

• br Conclusions There is significant

  2021-02-01

  

  Conclusions There is significant interest in understanding the contribution of biological mechanisms to the non-linear/bilinear dose–response curves for DNA-reactive agents. Model monofunctional alkylating agents have datasets amenable to PoD determination for genotoxic effects in both in vitro a

• ABH expression is elevated in prostate carcinomas and

  2021-02-01

  

  ABH3 expression is elevated in prostate carcinomas and has been referred to as prostate cancer antigen-1 or PCA-1. ABH3/PCA-1 was proposed as a diagnostic marker for prostate cancers, and suggested as a possible therapeutic target [82]. However, the recent studies of ABH2 and ABH3-null mice indicate

• DGK is a key enzyme in glucose uptake in skeletal

  2021-02-01

  

  DGKδ is a key enzyme in glucose uptake in skeletal muscle. Chibalin et al. demonstrated that a decrease in DGKδ expression increases the severity of type 2 diabetes [20]. Additionally, DGKδ expression was increased in people who exhibited enhanced insulin sensitivity after exercise training [56]. Fr

14690 records 677/980 page Previous Next First page 上5页 676677678679680 下5页 Last page