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The identification of distinct expression
2021-10-29
The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category
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The F P concentration reported
2021-10-29
The F6-P concentration reported for a resting rabbit muscle [20] reduced the KAapp for aldolase–FBPase complex more than 50 times compared to KAapp for aldolase–FBPase in the absence of effectors (Fig. 1b and Table 1). A standard assay for determination of FBPase activity in a complex with aldolase
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Defining the cooperation between molecular pathways within
2021-10-29
Defining the cooperation between molecular pathways within highly complex biological systems, such as those between immune cell networks and target tissues is certainly a hard task. Recently, there are many investigations in the pathogenesis of renal graft rejection, one of the most evident investig
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br Acknowledgments br Introduction Prenyltransferase catalyz
2021-10-29
Acknowledgments Introduction Prenyltransferase catalyzes the head-to-tail condensation between isopentenyl diphosphate (IPP, 1) and an allylic prenyl diphosphate to produce several prenyl diphosphates, which are then converted into steroids, carotenoids, prenyl side-chains of quinones, and pre
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Here we report a new human genetic disorder
2021-10-29
Here, we report a new human genetic disorder in a patient with hypoalgesia, altered fear and memory symptoms, and a non-anxious disposition. This disorder is attributable to co-inheritance of a microdeletion in a novel pseudogene and a known FAAH hypomorphic SNP. The microdeletion is flanked by repe
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chembridge br Sources of funding This work was supported by
2021-10-29
Sources of funding This work was supported by grants from the Canadian Institutes of Health Research (CIHR) (No. MOP-111096) and from the Heart and Stroke Foundation of Canada awarded to Dr. Danielle Jacques. Disclosures Acknowledgments Introduction A large number of epidemiological, h
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Not only does G a GLP
2021-10-29
Not only does G9a/GLP complex appear to play a role (albeit a seemingly conflicting one) in LTP maintenance, it may also be involved in long-term depression (LTD) (). At hippocampal CA1 synapses, LTD can be induced by pharmacological or synaptic stimulation of Group 1 metabotropic glutamate receptor
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It has been demonstrated that RA regulates gene
2021-10-29
It has been demonstrated that RA regulates gene BIIB021 through an epigenetic mechanism during stem cell and cancer cell differentiation. In neuroblastoma cells, RA induced neural maturation through RET gene transcriptional activation by increasing H3K4me3 levels at the promoter region and demethyl
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ponceau stain Electrochemical techniques have attracted broa
2021-10-29
Electrochemical techniques have attracted broad attention for their outstanding advantages, such as satisfactory sensitivity and convenient operation. Nowadays, nucleic ponceau stain nanostructures such as DNA tetrahedron structure, nucleic acid-mimicking structure, exhibit noticeable application i
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br Histamine attenuates the cognitive
2021-10-29
Histamine attenuates the cognitive impairing effects of early postnatal maternal deprivation Histamine acting on H2 receptors in the hippocampal CA1 region is able to reverse the deleterious effect of the exposure of rats to partial postnatal maternal deprivation on their memory consolidation of
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Bile acids synthesized in the liver are secreted into the
2021-10-29
Bile acids synthesized in the liver are secreted into the intestinal tract to facilitate the digestion and Flavin adenine dinucleotide of nutrients. Most bile acids are reabsorbed by the ileum and are transported back to the liver via the portal blood circulation. Recently, bile acids have also bee
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Several layers of regulation for this canonical
2021-10-28
Several layers of regulation for this canonical activation of the HH pathway exist. First, the protein kinase A (PKA), the casein kinase 1α (CK1α) and GSK3β can phosphorylate and mark for proteosomal degradation the GLI transcription factors. [36] Second, Suppressor of Fused (SUFU) binds to GLI and
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br Material and methods br Results and discussion Unlike man
2021-10-28
Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of amoxicillin price biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, are called non
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While PLGA implants could be
2021-10-28
While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they 7ACC2 could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, which might hamper t
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The opposite modulation observed for
2021-10-28
The opposite modulation observed for circulating LPI levels and WAT GPR55 324 4 synthesis by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. However
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