• Protein protein interaction networks are an important ingred

  2025-01-27

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• br Mechanism of action In general

  2025-01-27

  

  Mechanism of action In general, the main targets for antifungal drug development are cell wall polymer (glucans, chitin, mannoproteins), cell membrane (especially ergosterol) biosynthesis, DNA and protein synthesis (topoisomerases, nucleases, elongation factors and myristoylation), and signal tra

• The radiographic correlate will be similarly important for

  2025-01-27

  

  The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary (S)-Mephenytoin neoplasms. It has been reported that icotinib and gefitinib, epidermal growth factor rec

• br Introduction Heart failure HF is a

  2025-01-27

  

  Introduction Heart failure (HF) is a chronically progressive disease and one of the most important causes of morbidity and mortality worldwide despite recent improvements in its treatment [1], [2], [3]. The mortality and morbidity benefits of angiotensin converting enzyme inhibitor (ACEI) are wel

• Although several studies indicate that ALDH protects

  2025-01-26

  

  Although several studies indicate that ALDH2 protects the heart from injury and maladaptive remodeling (reviewed in [11], [12], [13]), accumulating evidence indicates that deficiency of the enzyme could be protective as well. For example, mice expressing the defective Aldh2*2 mutation show lower ald

• Estradiol Cypionate Polycyclic aromatic hydrocarbons PAHs ar

  2025-01-26

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, Estradiol Cypionate burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAH

• br Introduction Myasthenia gravis MG is an autoimmune diseas

  2025-01-26

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against SC 560 receptor receptor (AChR) [1]. In AChR negative MG patien

• It is important to note that stable

  2025-01-26

  

  It is important to note that stable amnesia is, apparently, a general biological phenomenon and can be found in different animal species. In studies on rats, it was found that if reconsolidation of conditioned olfactory aversion memory was impaired by the antagonist of NMDA glutamate receptors, amne

• Roles of Aurora kinases in

  2025-01-26

  

  Roles of Aurora kinases in directly activating multiple oncogenic pathways and promoting proliferation as well as transformation have also been demonstrated. Aurora-A has been shown to up-regulate telomerase reverse transcriptase mRNA through c-myc [26]. The kinase was also implicated in activating

• Introduction The first use of

  2025-01-26

  

  Introduction The first use of the term “autophagy” by a French physiologist, M. Anselmier, in a short article describing the effects of fasting in mice published in 1859, took place almost a century before Christian De Duve described it from a mechanistic point of view in a symposium on lysosomes i

• Matthew et al synthesized and carried

  2025-01-26

  

  Matthew et al. synthesized and carried out SAR studies of imidazo-[1,2-a]-pyrazine as Aurora kinase inhibitors with enhanced kinase selectivity and found that DBIBB 39 showed optimal potency on Aurora-A and Aurora-B with IC50 value of 4 nM and 13 nM while on phosphorylation histone H3 (pHH3), EC50

• In our H K ATPase assay

  2025-01-26

  

  In our H+, K+-ATPase assay (Fig. 1 and Supplementary Fig. 1), myricetin (IC50 = 0.58μM) was more potent than acid-activated omeprazole (IC50 = 1.50μM). In contrast, in oral administration in mice (Fig. 3), omeprazole (20mg/kg) more effectively inhibited gastric mCherry mRNA poly(A) tail secretion co

• br Conclusions In summary aromatase

  2025-01-26

  

  Conclusions In summary, aromatase mRNA expression in the NVP-BSK805 of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain of A. lepto

• Besides Arg overexpression our data

  2025-01-26

  

  Besides Arg2 overexpression, our data revealed that AGEs could decrease eNOS mRNA levels, which is considered a significant cause for attenuated NO production and vasodilation. It was found recently that AGEs significantly reduce eNOS expression levels and NO bioavailability in human carotid artery

• 2510 Similar to the importance of MeJA in postharvest A

  2025-01-26

  

  Similar to the importance of MeJA in postharvest A. bisporus quality maintenance at 10°C storage (Meng et al., 2012a), MeJA was also observed to play a pivotal role in this event at 4°C storage. Cap opening is an important mushroom quality indicator (Braaksma et al., 1999). During postharvest storag

14661 records 18/978 page Previous Next First page 上5页 1617181920 下5页 Last page