• AP activity is increased by

  2024-03-15

  

  AP-1 activity is increased by MAP kinase stimulation in different cell types (Whitmarsh and Davis, 1996), while MKP-1, the enzyme that catalyzes the dephosphorylation and inactivation of MAP kinases in the nucleus, inhibits AP-1 (Rössler et al., 2008, Rössler and Thiel, 2009, Mayer et al., 2011, Thi

• br AR mediated actions in cells of the vascular wall

  2024-03-14

  

  AR-mediated actions in benzbromarone of the vascular wall Sex hormones may influence the size and composition of atherosclerotic lesions indirectly by modifying systemic cardiovascular risk factors such as plasma lipids profiles and insulin sensitivity; this aspect of their action is discussed e

• br The lipoxygenase pathway in diseases

  2024-03-14

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic am580 and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the functions of 12- and 1

• In AD and possibly other forms of dementia it

  2024-03-14

  

  In AD, and possibly other forms of dementia, it has been suggested that tau mislocalization to dendritic spines anticipates neurodegeneration [48]. Accumulation of hyperphosphorylated tau in dendritic spies would cause a derangement of synaptic function, thereby impairing excitatory synaptic transmi

• Differentiation of skeletal myoblasts is a tightly orchestra

  2024-03-14

  

  Differentiation of skeletal myoblasts is a tightly orchestrated process that involves myoblast proliferation, CHIR-98014 withdrawal, expression of muscle-specific genes, and fusion into multinucleated myofibers (Horsley and Pavlath, 2004; Krauss, 2010). The maintenance of muscle mass is important f

• We have previously shown that the human

  2024-03-14

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor UNC 3230 (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight in t

• Adenosine is an endogenous nucleoside that

  2024-03-14

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the ampar and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors (

• vivit br Materials and methods br Results br Discussion

  2024-03-14

  

  Materials and methods Results Discussion Prostate cancer represents an ideal candidate for chemoprevention because of its high incidence and long latency to clinically significant disease [17]. The precancerous lesion PIN may also be a suitable target for ablation in chemoprevention strateg

• The srd a isoforms showed unique expression

  2024-03-14

  

  The srd5a isoforms showed unique expression profiles in early FHM development (Fig. 2). Similar to amphibian embryos, there was a high abundance of both srd5a1 and srd5a3 at 1dpf in FHMs, suggesting that mRNA for these enzymes may be maternally deposited and that these enzymes may play a key role in

• br Patients and Methods br Results br Discussion

  2024-03-14

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl 848 is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et al also showed that down-r

• br Conflict of interest br Introduction Ovarian

  2024-03-14

  

  Conflict of interest Introduction Ovarian cancer is the most lethal gynecological malignancy, and ranks as the fifth leading cause of cancer death among women. The American Cancer Society estimates that about 22,280 new ovarian cancer cases and 14,240 deaths will occur in the United States in

• br Autophagy in hemorrhagic stroke About of all strokes case

  2024-03-14

  

  Autophagy in hemorrhagic stroke About 87% of all strokes cases are ischemic, the rest being hemorrhagic. ICH and SAH are the two major categories of hemorrhagic strokes (Bruder et al., 2014). Both types of stroke are associated with a high mortality and morbidity rate. The corresponding animal mo

• Several in vivo and in

  2024-03-13

  

  Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev

• br Conclusion br Acknowledgements br Introduction Synapses a

  2024-03-13

  

  Conclusion Acknowledgements Introduction Synapses are the fundamental elements of neuronal networks that enable the processing, encoding, and retrieval of information in the brain, and pathological disruptions in synapse structure are broadly held to underlie the development of neurological

• Most clinically approved antiangiogenic drugs are aimed

  2024-03-13

  

  Most clinically approved antiangiogenic drugs are aimed at blocking the action of vascular endothelial growth factor, or VEGF, which is accepted to be the most important tumor-derived angiogenic factor, stimulating proliferation and migration of endothelial cells, as well as branching of vessels (Fe

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