• Angiotensin II in Abdominal Aortic Aneurysm: Linking GPCR...

  2025-09-23

  Explore the multifaceted role of Angiotensin II in abdominal aortic aneurysm research, emphasizing its function as a potent vasopressor and GPCR agonist. This article highlights emerging connections between angiotensin receptor signaling, cellular senescence, and vascular remodeling mechanisms.

• BGJ398 (NVP-BGJ398): Selective FGFR Inhibition for Cancer...

  2025-09-22

  Explore the research applications of BGJ398 (NVP-BGJ398), a highly selective FGFR inhibitor, in oncology and developmental biology. This article discusses its mechanism of action, relevance in FGFR-driven malignancies research, and the broader implications of FGFR signaling modulation.

• Protease Inhibitor Cocktail EDTA-Free: Safeguarding Prote...

  2025-09-19

  This article explores the critical role of Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) in preserving protein complexes during extraction and purification, focusing on its a

• Pseudo-modified Uridine Triphosphate: Advancing RNA Thera...

  2025-09-18

  Pseudo-modified uridine triphosphate (Pseudo-UTP) is transforming the landscape of mRNA synthesis by enabling enhanced RNA stability, translation, and reduced immunogenicity—key factors for mRNA vaccine development and gene therapy. This article explores the biochemical and translational impact of Pseudo-UTP in in vitro transcription and its implications for next-generation RNA therapeutics.

• br Study approval br Author contributions br

  2025-03-03

  

  Study approval Author contributions Conflicts of interest Acknowledgements This work was supported by grants of the Youth Backbone Program (to Jianming Ying) of Cancer Hospital, CAMS, Beijing, Beijing Hope Run Special Fund of Cancer Foundation of China (LC2015A06) and the National Natura

• br Acknowledgements Dr Paul J Gasser

  2025-03-03

  

  Acknowledgements Dr. Paul J. Gasser is supported by the National Institutes of Health (grant number R01DA032895), and the Charles E. Kubly Mental Health Research Center. Dr. Christopher A. Lowry is supported by the National Institutes of Health (grant number R21 MH116263), the Department of the N

• Involvement of Adiponectin in the regulation of imatinib res

  2025-03-03

  

  Involvement of Adiponectin in the regulation of imatinib resistance in human CML cells has not been hitherto examined. Therefore, in this study, we first established imatinib-resistant K562 CML cells, and then evaluated the effect of Adiponectin in reversing imatinib resistance. The data presented h

• The altered frequency of CD T cells

  2025-03-03

  

  The altered frequency of CD4+ T Koumine sale in 5-LO−/− mice led us to hypothesize that these leukocytes could be exerting a primary control of the inflammatory response. In fact, the lack of 5-LO resulted in the accumulation of CD4+CD25+ cells expressing Treg markers. It is plausible to speculate

• Because LTs are proved to mediate multiple

  2025-03-03

  

  Because LTs are proved to mediate multiple biological and pathological responses in various disease states, the 5-LO biosynthetic pathway producing LTs from AA have been the target of drug discovery efforts for over two decades. As observed from literature, a pile of research efforts has been direct

• Pompe disease is accompanied by the

  2025-03-03

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the Human metabolite unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in

• The take home message here

  2025-03-03

  

  The take-home message here is that, although Aurora A phosphorylated on T288 is the activated isoform of Aurora A, measuring the level of phosphorylation of T288 does not reflect Aurora A kinase activity (Figure 5). What would be the most appropriate readout for an in vivo Aurora A kinase activity

• br Results br Discussion br Conclusion The flux of

  2025-03-01

  

  Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta Beclomethasone dipropionate in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting tha

• br Introduction In addition to ATP

  2025-03-01

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric Trobalt cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites that stimulate and/or

• Bioavailability has been defined as the amount of a

  2025-03-01

  

  Bioavailability has been defined as the amount of a drug given by any route, other than intravenously, that reaches general circulation and is available at the site of action [86]. The low bioavailability observed with the initial intravaginal devices (16%) was attributed to the melting point of the

• br Conclusions In summary KLA isolated from K senegalensis e

  2025-03-01

  

  Conclusions In summary, KLA isolated from K. senegalensis exerted the anti-inflammatory activity via inhibiting the activation of NF-κB, AP-1, AKT and upregulating p38 MAPK/Nrf2/HO-1 signaling in LPS-stimulated RAW 264.7 and BV-2 NP118809 (Fig. 9). These properties provide a potential mechanism

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